Information Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively. Targets caspases-1 (Cell-free assay); caspases-5 (Cell-free assay); caspases-4 (Cell-free assay) 46.7 nM; 329 nM; 1.49 μM In vitro A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes. In vivo Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury. Cell Research(from reference) Cell lines：BMDM cells Concentrations：10 μM Incubation Time：30 mins
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Ac-FLTD-CMK
CAS number：2376255-48-8 molecular formula：C26H37ClN4O8
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| Chinese alias | - | ||
| English alias | N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone | ||
| CAS number | 2376255-48-8 | molecular formula | C26H37ClN4O8 |
| molecular weight | 569.05 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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