Information BO-264 BO-264 is a potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3) with IC50 of 188 nM and Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces SAC-dependent mitotic arrest, apoptosis and DNA damage with antitumor activities. Targets FGFR3 ; TACC3 (Cell-free assay); TACC3 (Cell-free assay) ; 1.5 nM(Kd); 188 nM In vitro BO-264 significantly decreases centrosomal TACC3 during both mitosis and interphase. BO-264 displays potent anti-proliferative activity in the NCI- 60 cell line panel compromising nine different cancer types. BO-264 significantly inhibits the growth of cells harboring FGFR3-TACC3 fusion, an oncogenic driver in diverse malignancies. In vivo BO-264\'s oral administration significantly impairs tumor growth in immunocompromised and immunocompetent breast and colon cancer mouse models, and increases survival without any major toxicity. Cell Research(from reference) Cell lines：JIMT-1 cells Concentrations：1 μM Incubation Time：6 h
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BO-264
CAS number：2408648-20-2 molecular formula：C18H19N5O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2408648-20-2 | molecular formula | C18H19N5O3 |
| molecular weight | 353.38 g/mol | Exact mass | ≥99% |
| PSA | 85.500 Ų | logp | 3.02 |
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