Pyridoclax is a potential Mcl-1 inhibitor. In Vitro Pyridoclax directly binds to Mcl-1. Without cytotoxic activity when administered as a single agent, Pyridoclax induces apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells. Pyridoclax directly binds to Mcl-1, and hence sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies. Pyridoclax induces apoptosis in ovarian, and also in lung, and mesothelioma cancer cells when it is administrated in combination with Bcl-xL-targeting siRNA or Bcl-xL targeting molecules such as ABT-737 or its orally available derivative ABT-263. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Mcl-1
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Pyridoclax
CAS number：1651890-44-6 molecular formula：C29H22N4
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| Chinese alias | 吡啶酮 | ||
| English alias | - | ||
| CAS number | 1651890-44-6 | molecular formula | C29H22N4 |
| molecular weight | 426.51 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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