MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand. In Vitro MV1 (0.08-20 μM; 24 h) inhibits the growth of EVSAT cells. MV1 (5 μM; 0-60 min) treatment causes rapid loss of c-IAP1 and c-IAP2 in MDA-MB-231 cells. MV1 (5 μM; 1 h) treatment inducing degradation of c-IAP1 and c-IAP2 is dependent on proteasomal machinery but not on caspase activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: EVSAT cells Concentration: 0.08-20 μM Incubation Time: 24 hours Result: Showed IC 50 value of 5 μM for EVSAT cells. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 5 μM Incubation Time: 0-60 min Result: Showed the decreasement of c-IAP1 and 2 protein levels by as early as two minutes following exposure. Form:Solid
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MV1
CAS number：1001600-54-9 molecular formula：C33H44N4O5
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Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1001600-54-9 | molecular formula | C33H44N4O5 |
| molecular weight | 576.73 g/mol | Exact mass | ≥99% |
| PSA | 117.000 Ų | logp | 4.700 |
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