COX-1抑制剂II是靶向Cox催化位点（环加氧酶）的可透过细胞的苯磺酰胺化合物。COX-1抑制剂II抑制Cox-1（IC | 50 |为3.2μM）的选择性要高于Cox-2（IC | 50 |大于100μM）。与阿司匹林相似，COX-1抑制剂II具有相似的体内止痛活性，但与阿司匹林和消炎痛不同，COX-1抑制剂II不会引起胃功能紊乱。揭示该化合物除了抑制Cox-2表达外，还抑制PCA反应，并通过抑制ERK的磷酸化发挥抗炎作用。 COX-1 Inhibitor II is a cell-permeable benzenesulfonamide compound that targets the catalytic site of Cox (cyclooxygenase). COX-1 Inhibitor II inhibits Cox-1 (IC|50|of 3.2 μM) more selectively than Cox-2 (IC|50|of > 100 μM). Much like Aspirin , COX-1 Inhibitor II has shown similar|in vivo|analgesic activity, yet unlike Aspirin and Indomethacin, COX-1 Inhibitor II does not induce gastric disturbance. The compound was revealed to inhibit PCA response in addition to Cox-2 expression and to exert anti-inflammatory effects by suppressing phosphorylation of ERK.
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COX-1 Inhibitor II
CAS number：304913-22-2 molecular formula：C13H13ClN2O2S
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| Chinese alias | - | ||
| English alias | SCHEMBL16211204 | 4-amino-N-(4-chlorophenyl)-N-methylbenzenesulfonamide | BDBM50197708 | COX-1 Inhibitor II | DTXSID20583128 | J-017989 | Benzenesulfonamide, 4-amino-N-(4-chlorophenyl)-N-methyl- | 4-Amino-N-(4-chlorophenyl)-N-methylbenzene-1-sulfonamide | | ||
| CAS number | 304913-22-2 | molecular formula | C13H13ClN2O2S |
| molecular weight | 296.8 g/mol | Exact mass | ≥95% |
| PSA | 71.800 Ų | logp | 2.600 |
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