Information Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibitAChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production. Targets AChE In vitro Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. It decreases intracellular calcium levels in primary cortical neurons. In vivo Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors. DHED significantly improves learning and memory in the Aβ 1-42 -infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production. Cell Research(from reference) Cell lines：primary cortical neurons Concentrations：0.5 and 1 µM Incubation Time：4 h
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Dehydroevodiamine hydrochloride
CAS number：111664-82-5 molecular formula：C19H15N3O.HCl
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,14-dihydro-14-methyl-,hydrochloride (1:1) | ||
| CAS number | 111664-82-5 | molecular formula | C19H15N3O.HCl |
| molecular weight | 337.8 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | 2.891 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
