Naproxen etemesil is a lipophilic, non-acidic, inactive proagent of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC 50 s of 8.72 and 5.15 μM, respectively in cell assay. In Vitro Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC 50 s of 2.2 μg/mL and 1.3 μg/mL, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC 50 =27, 40, 13 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 8.72 μM (COX-1), 5.15 μM (COX-2)
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Naproxen etemesil
CAS number：385800-16-8 molecular formula：C17H20O5S
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| Chinese alias | 萘普生乙酯 | ||
| English alias | 2-methylsulfonylethyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate | 2-NAPHTHALENEACETIC ACID, 6-METHOXY-.ALPHA.-METHYL-, 2-(METHYLSULFONYL)ETHYL ESTER, (.ALPHA.S)- | HY-19675 | (S)-2-(methylsulfonyl)ethyl 2-(6-methoxynaphthalen-2-yl)propanoate | UNII-2142 | ||
| CAS number | 385800-16-8 | molecular formula | C17H20O5S |
| molecular weight | 336.40 g/mol | Exact mass | ≥99% |
| PSA | 78.100 Ų | logp | 2.5 |
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