PD-1/PD-L1-IN-9 hydrochloride is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC 50 of 3.8 nM. PD-1/PD-L1-IN-9 hydrochloride can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 hydrochloride also exh Appearance:Solid In Vitro:PD-1/PD-L1-IN-9 hydrochloride (compound 24) (46.9-1500 nM; pretreated for 2 h) dose-dependently significantly activates the antitumor immunity of peripheral blood mononuclear cells (PBMCs) to MDB-MB 231 cells, with an EC 50 of ∼100 nM. MCE has not in In Vivo:PD-1/PD-L1-IN-9 hydrochloride (compound 24) (40-80mg/kg; p.o.; once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner and does not cause any body weight loss or mortality of mice. PD-1/PD-L1-IN-9 hydrochloride (3mg/kg; i.v.; singl Biological Activity:PD-1/PD-L1-IN-9 hydrochloride is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC 50 of 3.8 nM. PD-1/PD-L1-IN-9 hydrochloride can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 hydrochloride also exh
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PD-1/PD-L1-IN-9 hydrochloride
CAS number：unknown molecular formula：C22H25ClN2O2
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| Chinese alias | PD-1/PD-L1-IN-9盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C22H25ClN2O2 |
| molecular weight | 384.9 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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