结合珠蛋白,表型1-1,人血浆

在三种触珠蛋白表型中，Hp 1-1在结合游离血红蛋白和抑制与游离血红蛋白相关的炎症反应方面最有效。Hp 1-1可预防糖尿病的血管并发症，与镰状细胞贫血有关，在肝硬化病例中比其他表型更常见。 表型1-1的个体血浆中触珠蛋白浓度最高。 Of the three haptoglobin phenotypes, Hp 1-1 is the most effective in binding free hemoglobin and in suppressing the inflammatory responses associated with free hemoglobin. Hp 1-1 protects against vascular complications in diabetes, is associated with sickle cell anemia, and is more common than other phenotypes in cases of cirrhosis.Individuals who are phenotype 1-1 have the highest concentration of haptoglobin in plasma. Product Citations: Chen-Roetling J, Regan RF.Haptoglobin increases the vulnerability of CD163‐expressing neurons to hemoglobin.J Neurochem. 2016 Nov;139(4):586-595. doi: 10.1111/jnc.13720. Epub 2016 Jul 22. Xu S, Kaltashov IA.Evaluation of Gallium as a Tracer of Exogenous Hemoglobin-Haptoglobin Complexes for Targeted Drug Delivery Applications.J Am Soc Mass Spectrom. 2016 Dec;27(12):2025-2032. Epub 2016 Sep 12. Fatunmbi O, Abzalimov RR, Savinov SN, Gershenson A, Kaltashov IA.Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry.Biochemistry. 2016 Mar 29;55(12):1918-28. doi: 10.1021/acs.biochem.5b00807. Epub 2016 Mar 17.

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