荧光鬼笔毒素可用于鉴定丝状肌动蛋白。鬼笔环肽-四甲基罗丹明B异硫氰酸酯已被用于：-在免疫荧光中对丝状肌动蛋白（F-actin）进行染色在免疫细胞化学和细胞化学分析过程中对细胞进行染色标记肌动蛋白微丝以进行荧光显微镜检查应用： 鬼笔环肽是由死亡之帽鬼笔鹅膏产生的鬼笔毒素。它是一种可与肌动蛋白相互作用的环状肽，最早是在鬼笔环肽中毒的大鼠中发现的。它是一种七肽，本质上是环状的，在6位色氨酸和3位半胱氨酸之间具有交联键。鬼笔环肽中的氨基酸7（γ-δ-二羟基亮氨酸）的侧链可以进行修饰，通过该修饰可以产生荧光标记的鬼笔环肽化合物。 Phalloidin is a phallotoxin produced by death cap mushroom Amanita phalloides . It is a cyclic peptide, which interacts with actin, and this was first identified in phalloidin-poisoned rats. It is a heptapeptide, cyclic in nature, with a crosslink between tryptophan at position 6 and cysteine at position 3. The side chain of amino acid 7 (γ-δ-dihydroxyleucine) in phalloidin, is accessible to modifications, through which florescent labelled phalloidin compounds can be produced. Application: Fluorescent phallotoxin which may be used to identify filamentous actin. Phalloidin-Tetramethylrhodamine B isothiocyanate has been used:- In Immunofluorescence for staining Filamentous actin (F-actin) To stain cells during immunocytochemical and cytochemical analysis To label actin microfilaments for fluorescence microscopy
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鬼笔环肽-四甲基罗丹明B异硫氰酸盐
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | sequence from Amanit |
| PSA | - | logp | - |
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