compound introduction
Implitapide (AEGR 427) is a microsomal triglyceride transfer protein ( MTP ) inhibitor. In Vitro Implitapide suppresses MTP activity using a recombinant human form complexed with protein disulphide isomerase (IC 50 =10 nM) and inhibit secretion of apoB-containing very low-density lipoprotein (VLDL)-like lipoproteins from a human hepatoma cell (HepG2) with an IC 50 value of 1.1 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Implitapide (3.2 mg/kg/d) significantly reduces the plasma lipid levels to nearly or below the chow diet (CD) level at 4 and 8 weeks of treatment (p Form:Solid IC50& Target:MTP
