BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 ( PAR4 ) antagonist, with IC 50 s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects In Vitro BMS-986120 has high binding affinity to PAR4 expressed on HEK293 cells and inhibition of PAR4-induced calcium mobilization with an IC 50 of 0.56 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In monkeys, BMS (1 mg/kg) does not inhibit PA induced by PAR1-AP, ADP and collagen, supporting selectivity. BMS (0.2, 0.5, 1 mg/kg) reduces TW by 35±5, 49±4, and 83±4%, respectively. Maximum KBT and MBT increases are only 2.2-fold and 1.8-fold, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 9.5 nM (PAR4, human), 2.1 nM (PAR4, monkey)
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BMS-986120
CAS number：1478712-37-6 molecular formula：C23H23N5O5S2
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| Chinese alias | - | ||
| English alias | HY-19837 | SCHEMBL15348871 | WDT28B7071 | BMS 986120 | BDBM176061 | 4-(4-{[(6-methoxy-2-{2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl}-1-benzofuran-4-yl)oxy]methyl}-5-methyl-1,3-thiazol-2-yl)morpholine | 1478712-37-6 | EX-A3977 | Imidazo(2,1-b)-1,3,4-thi | ||
| CAS number | 1478712-37-6 | molecular formula | C23H23N5O5S2 |
| molecular weight | 513.59 g/mol | Exact mass | ≥98% |
| PSA | 153.000 Ų | logp | 4.200 |
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