compound introduction
AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen ( PCNA ) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis . AOH1160 selectively kills many types of cancer cells (mean GI 50 =330 nM) without causing significant toxicity to a broad range of nonmalignant cells Form:Solid IC50& Target:IC50: PCNA
