PC786 is an inhaled respiratory syncytial virus ( RSV ) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against RSV-A ( IC 50 In Vitro PC786 demonstrates a potent and selective antiviral activity against laboratory-adapted or clinical isolates of RSV-A (IC 50 In Vivo Once-daily treatment with PC786, on days-1 to 3, by either intratracheal (i.t.) or intranasal (i.n.) administration, is found to inhibit viral loads in the lungs of RSV A2-infected BALB/c mice. The viral load is below the level of detection when the drug is given at 2 mg/mL (40 μg/mouse [approximately 1.6 mg/kg of body weight] for i.t. treatment, or 80 μg/mouse [approximately 3.2 mg/kg] for i.n. treatment) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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PC786
CAS number：1902114-15-1 molecular formula：C41H38FN5O4S
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| Chinese alias | - | ||
| English alias | 1902114-15-1 | AKOS032954132 | MC0MD9J0F4 | PC786 | PC-786 | MS-31215 | UNII-MC0MD9J0F4 | N-(2-Fluoro-6-methylphenyl)-5,6-dihydro-6-(4-(((5-methyl-2-(7-oxa-2-azaspiro(3.5)non-2-yl)-3-pyridinyl)carbonyl)amino)benzoyl)-4H-thieno(3,2-d)(1)benzazepine-2-carbo | ||
| CAS number | 1902114-15-1 | molecular formula | C41H38FN5O4S |
| molecular weight | 715.83 g/mol | Exact mass | ≥99% |
| PSA | 132.000 Ų | logp | 6.8 |
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