FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo In Vivo FR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Inbred male Balbuc mice (aged 8 weeks) Dosage: 32 kg/mg Administration: Subcutaneous injection; 24-48 hours Result: The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla. Form:Solid IC50& Target:p38 MAPK
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FR 167653
CAS number：158876-66-5 molecular formula：C24H20FN5O6S
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| Chinese alias | 法国 167653 | ||
| English alias | - | ||
| CAS number | 158876-66-5 | molecular formula | C24H20FN5O6S |
| molecular weight | 525.51 g/mol | Exact mass | ≥99% |
| PSA | 163.000 Ų | logp | - |
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