TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC 50 s of 36 and 22 nM for TRα and TRβ, respectively. In Vitro TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC 50 =36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC 50 32 nM for both TRAFα1 and TRAFβ1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 36 nM (Thyroid hormone α), 22 nM (Thyroid hormone α)
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TR antagonist 1
CAS number：500794-88-7 molecular formula：C25H23Br2NO4
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| Chinese alias | TR 拮抗剂 1 | ||
| English alias | - | ||
| CAS number | 500794-88-7 | molecular formula | C25H23Br2NO4 |
| molecular weight | 561.26 g/mol | Exact mass | ≥98% |
| PSA | 79.700 Ų | logp | 6.600 |
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