KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor , inhibits specific [ 3 H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC 50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent In Vitro KB-5492 (0.001-100 μM) inhibits specific [ 3 H]DTG binding in a concentration-dependent manner. KB-5492 (0.1-1 mM) significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51 Cr release from gastric epithelial cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo KB-5492 (200 mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damageDosage: 200 mg/kg Administration: Oral gavage Result: Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells. Form:Solid IC50& Target:IC50: 3.15 μM (sigma receptor)
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KB-5492 anhydrous
CAS number：129200-10-8 molecular formula：C27H34N2O10
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| Chinese alias | - | ||
| English alias | 1-Piperazineacetic acid, 4-((3,4,5-trimethoxyphenyl)methyl)-, 4-methoxyphenyl ester, (E)-2-butenedioate (1:1) | KB-5492 | HY-19120 | MS-30020 | AKOS040745939 | KB-5492 anhydrous | 1-(3,4,5-Trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine | ||
| CAS number | 129200-10-8 | molecular formula | C27H34N2O10 |
| molecular weight | 546.57 g/mol | Exact mass | ≥99% |
| PSA | 144.000 Ų | logp | - |
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