KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A , with an IC 50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases , and histone acetyl transferases In Vitro KDM2A/7A-IN-1 ((S,S)-6) is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC 50 of 0.16?μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive to methyl transferases, and histone acetyl transferases. ? KDM2A/7A-IN-1 (0.4, 3.1, 6.2 μM) augments cellular H3K36me2 levels in HeLa cells ectopically expressing catalytically active KDM2A. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:KDM2
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KDM2A/7A-IN-1
CAS number：2169272-46-0 molecular formula：C33H38N4O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2169272-46-0 | molecular formula | C33H38N4O |
| molecular weight | 506.68 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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