CAS number：168266-51-1 molecular formula：C21H25Cl2F3N6O
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [ 3 H]SP binding to the NK1 receptor with pK i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent Form:Solid IC50& Target:pKi: 9.5 (NK1, rat), 10.6 (NK1, human)
| Chinese alias | 盐酸沃福匹坦 | ||
| English alias | (2S,3S)-N-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]-2-phenylpiperidin-3-amine dihydrochloride | HY-12143 | [2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)benzyl]-([2S,3S]-2-phenylpiperidin-3yl)amine dihydrochloride | VOFOPITANT DIHYDRO | ||
| CAS number | 168266-51-1 | molecular formula | C21H25Cl2F3N6O |
| molecular weight | 505.36 g/mol | Exact mass | ≥99% |
| PSA | 76.900 Ų | logp | - |
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