AMG7703 is a selective and allosteric agonists of FFA2 ( GPR43 ), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic. In Vitro AMG7703 (phenylacetamide 1) (30 μM) shows selectivity on FFA2 (GPR43) over FFA1 (GPR40) and FFA3 (GPR41) with in Chinese hamster ovary cells. AMG7703 (0.041, 0.123, 0.37, 1.11 μM) acts as an FFA2 allosteric agonist, activates Gα i coupled signaling pathway. AMG7703 (1, 3, 10, 30 μM) results in Gα i -dependent inhibition of lipolysis in adipocytes (3T3L1). AMG7703 (0.041, 0.123, 0.37, 1.11 μM) exhibits allosteric activity and inhibits Gα i -coupled cAMP with IC 50 values of 0.7 μM (hFFA2) and 0.96 μM (mFFA2), respectively; as for Gα q -coupled aequorin inhibition, with EC 50 s of 0.45 μM (hFFA2) and 1.27 μM (mFFA2), respectively. AMG7703 (0-1 μM) shows the positive cooperating effect of acetate and stimulates calcium mobilization in a concentration-dependent manner in CHO cell stably expressing hFFA2 and aequorin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
AMG7703
CAS number：1103523-24-5 molecular formula：C14H15ClN2OS
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1103523-24-5 | molecular formula | C14H15ClN2OS |
| molecular weight | 294.80 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
