Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively In Vitro Nampt-IN-5 (compound 27) (0-10 nM; 3 days) has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min•mg), CYP3A4 inhibition value (0.75 μM), Sol 6.8 : 0.056 mM; MDCK P app AB: 18.6. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Nampt-IN-5 (5-30 mg/kg; p.o. twice daily for 4 days) causes a significant amount of body weight loss in nude mice relative to vehicle . Nampt-IN-5 (10 mg/kg; p.o.) exhibits T 1/2 (2.1 h), C max (29112 nM), and AUC (61984 nM•h) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:NAMPT, CYP3A4
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Nampt-IN-5
CAS number：2380013-17-0 molecular formula：C25H25N5O2
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| Chinese alias | 南安普特-IN-5 | ||
| English alias | - | ||
| CAS number | 2380013-17-0 | molecular formula | C25H25N5O2 |
| molecular weight | 427.50 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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