DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor ( IC 50 =8.6 nM; K d =11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex. Appearance:Solid In Vitro:DDO-2093 (5 μM; pretreated 7 days) dihydrochloride inhibits MLL-fusion protein dependent genes expression ( HOXA9 and Meis1 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisC In Vivo:DDO-2093 (20-80mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. A Biological Activity:DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor ( IC 50 =8.6 nM; K d =11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex.
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DDO-2093 dihydrochloride
CAS number：unknown molecular formula：C29H39Cl3FN9O3
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| Chinese alias | DDO-2093 二盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C29H39Cl3FN9O3 |
| molecular weight | 687.04 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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