PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the Appearance:Solid In Vitro:PR-39 TFA, shown to selectively affect proteasomemediated protein degradation in vivo, alters the shape of the 20S and 26S cylinder and affects the binding of 19S caps in a reversible manner. PR-39 TFA specifically blocks degradation of IκBα and HIF-1α by In Vivo:PR-39 TFA (10mg/kg, intravenously; 1 hour before Caerulein of 50 μg/kg, ip) blocks IκBα degradation and NF-κB-dependent transcription in the mouse pancreas after induction of acute pancreatitis. PR-39 TFA (1 μg/kg/day; 7-day intraperitoneal infusion Biological Activity:PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the
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PR-39 TFA
CAS number：unknown molecular formula：C231H347F3N70O42
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| Chinese alias | PR-39 三氟乙酸 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C231H347F3N70O42 |
| molecular weight | 4833.76 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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