INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia. Appearance:Solid IC50& Target:KDM1/LSD1 In Vitro:INCB059872 (25 nM; 48 hours; 293T cells) dihydrochloride increases enhancer activity and gene expression. INCB059872 (25 nM; 24 hours; THP-1 cells) dihydrochloride makes THP-1 show a growth defect within one cell doubling time or approximately 3 days In Vivo:INCB059872 (10mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) dihydrochloride makes single-cell RNA-seq revealing changes in bone marrow progenitor populations. MCE has not independently confirmed the accuracy of these methods. They are for reference o Biological Activity:INCB059872 dihydrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 ( LSD1 ) inhibitor. INCB059872 dihydrochloride can be used for the research of myeloid leukemia.
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INCB059872 dihydrochloride
CAS number：unknown molecular formula：C23H36Cl2N2O3
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| Chinese alias | INCB059872 二盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C23H36Cl2N2O3 |
| molecular weight | 459.45 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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