PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC 50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form c Appearance:Solid IC50& Target:IC50: 11 nM (PRMT5/MEP50) In Vitro:PRMT5 IN-1 (compound 9; 0-500 nM) hydrochlorideinhibits the PRMT5/MEP50 complex [K inact /K I =1.2×10 5 M -1 min -1 ] very rapidly with a K inact of 0.068 min -1 and a good binding affinity (K I =55 nM). PRMT5 IN-1 (0-1000 nM; 3 d; Granta-519 cells) Biological Activity:PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC 50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form c
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PRMT5-IN-1 hydrochloride
CAS number：unknown molecular formula：C19H20Cl2N4O5
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| Chinese alias | PRMT5-IN-1盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C19H20Cl2N4O5 |
| molecular weight | 455.29 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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