CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier In Vivo CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Hypothyroid Wistar rats Dosage: 0.04, 0.8, 2.5, and 5.0 nmol/g Administration: Ip Result: Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective. Form:Solid IC50& Target:TRα
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
CO23
CAS number：1370363-74-8 molecular formula：C19H18I2N2O4
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1370363-74-8 | molecular formula | C19H18I2N2O4 |
| molecular weight | 592.17 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
