LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1 ) inhibitor with IC 50 s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (B Appearance:Solid IC50& Target:IC50: 4.8 nM (Adapter protein-2 associated kinase 1 (AAK1) in enzyme assays); 7.6 nM (AAK1 in cell assays); 24 nM (BMP-2-inducible protein kinase (BIKE)) In Vivo:In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1 ) inhibitor with IC 50 s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (
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LP-922761 hydrate
CAS number：unknown molecular formula：C21H26N6O3.1/4H2O
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| Chinese alias | LP-922761 水合物 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C21H26N6O3.1/4H2O |
| molecular weight | 414.98 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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