compound introduction
PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC 50 s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects. Appearance:Solid IC50& Target:IC50: 120 nM (PTP1B), 120 nM (TCPTP) In Vivo:In diet-induced obese (DIO) mice, PTP1B-IN-3 (compounds 3g) exhibits dose dependent inhibition (60%, 80% and 100% inhibition at 1, 3 and 10mg/kg, respectively) of glucose excursion when given orally 2 h before oral glucose challenge with an estimated ED Biological Activity:PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC 50 s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects .
