Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC 50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma Appearance:Solid IC50& Target:IC 50 : 50 nM (Mps1) In Vitro:Mps1-IN-3 hydrochloride (0.3-10 μM) inhibits the marker of mitotic cells cyclin B in a dose-dependent manner. Mps1-IN-3 hydrochloride (2 μM) causes a dose-dependent escape from a checkpoint-mediated mitotic arrest. Mps1-IN-3 hydrochloride (1-15 In Vivo:Mps1-IN-3 hydrochloride (2mg/kg; IV, twice a week, for 3 weeks) effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft models. MCE has not independently confirmed the accuracy of these methods. They are for referenc Biological Activity:Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC 50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma
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Mps1-IN-3 hydrochloride
CAS number：unknown molecular formula：C26H32ClN7O4S
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| Chinese alias | Mps1-IN-3 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C26H32ClN7O4S |
| molecular weight | 574.09 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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