AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC 50 s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2 , with K d s of 0.28 nM and 0.32 nM, respectively. AZ IC50& Target:PAK2 0.32 nM (Kd) PAK1 0.28 nM (Kd) PAK1 0.33 nM (IC 50 ) pPAK1 59 nM (IC 50 ) In Vitro:AZ13705339 (1 μM) hemihydrate inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells. AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death. MCE has not independently confirmed the accuracy of In Vivo:AZ13705339 hemihydrate (100mg/kg, P.O.) has moderate clearance and oral C max of 7.7 μM in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:AZ13705339 hemihydrate is a highly potent and selective PAK1 inhibitor with IC 50 s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities to PAK1 and PAK2 , with K d s of 0.28 nM and 0.32 nM, respectively. AZ
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AZ13705339 hemihydrate
CAS number：unknown molecular formula：C33H36FN7O3S.1/2H2O
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| Chinese alias | AZ13705339 半水合物 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C33H36FN7O3S.1/2H2O |
| molecular weight | 638.77 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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