GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC 50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of Appearance:Solid IC50& Target:IC50: 77.79 nM (Speckled 140 kDa, SP140) In Vitro:GSK761 combines with SP140 in HuT78 cells and HEK293 cells transfected with Halo-tagged SP140. GSK761 (0.01-1.11 µM; 1 h) reduces the inflammatory activation and down-regulates the expression of TNF, IL-6, IL-12p70, IL-1β, IL-8, IL-10 pro-inflammator Biological Activity:GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC 50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of
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GSK761
CAS number：unknown molecular formula：C40H46N4O4
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C40H46N4O4 |
| molecular weight | 646.82 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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