CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT , with IC 50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. Appearance:Solid IC50& Target:DNA Methyltransferase 32 nM (IC 50 ) DNMT1 1.5 nM (Kd) DNMT3A 92 nM (IC 50 ) DNMT3B 1000 nM (IC 50 ) G9a 16 nM (IC 50 ) In Vitro:The K d of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC 50 s of 92 nM and 1000 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT , with IC 50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.
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CM-579 trihydrochloride
CAS number：unknown molecular formula：C29H43Cl3N4O3
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| Chinese alias | CM-579 三盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C29H43Cl3N4O3 |
| molecular weight | 602.04 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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