JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) ( IC 50 =0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death. In Vitro JA2131 (10 mM; 1-2 h) induces hyperPARylation of PARP1 in PC3 cells. JA2131 (10 μM; 2 wk) inhibits colony formation of MCF-7, PC3, and MDA-MB-231 cells, and (0.1 μM-1 mM; 72 h) shows cytotoxicity to inhibit MRC-50 cells with an IC 50 value of 132 μM. JA2131 (5 μM; 72 h) inhibits PC3, and A172 glioblastoma cells viability. JA2131 (10 μM; 2 h) could be acting at the replication fork in HeLa cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: PC3, and A172 glioblastoma cells Concentration: 0.1 μM-10 mM Incubation Time: 72 hours Result: Inhibited cell viability with IC50s of 33.05 μM (PC3 cells) and 55.34 μM (A172 cells), respectively. Form:Solid
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JA2131
CAS number：6505-99-3 molecular formula：C13H19N5O2S2
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| Chinese alias | - | ||
| English alias | EX-A5812 | DTXSID10402359 | NSC98003 | NSC-98003 | HY-137924 | SCHEMBL24559257 | JA2131 | 1,3-dimethyl-8-(2-morpholin-4-ylethylsulfanyl)-6-sulfanylidene-7H-purin-2-one | ||
| CAS number | 6505-99-3 | molecular formula | C13H19N5O2S2 |
| molecular weight | 341.45 g/mol | Exact mass | ≥99% |
| PSA | 122.000 Ų | logp | 0.700 |
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