SGC-CK2-1

SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC 50 s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases In Vitro SGC-CK2-1 inhibits CSNK2A2 and CSNK2A1 with IC 50 s value of 2.3 and 4.2 nM. SGC-CK2-1 inhibits DYRK2 with the IC 50 value of 3.7 μM. SGC-CK2-1 inhibits blood U-937, MV4-11, MOLM-13, OCI-LY19, OCI-AML5 cells with IC 50 s of 120, 690, 750, 760 and 810 nM, respectively. SGC-CK2-1 inhibits Head/Neck Detroit562 cells with an IC 50 of 550 nM. SGC-CK2-1 inhibits Lung NCI-H2286 cells with an IC 50 of 550 nM. SGC-CK2-1 inhibits Brain SK-N-MC cells with an IC 50 of 730 nM. SGC-CK2-1 inhibits Breast BT-20 cells with an IC 50 of 810 nM. SGC-CK2-1 inhibits Skin A375 cells with an IC 50 of 830 nM. SGC-CK2-1 inhibits Stomach SNU-1 cells with an IC 50 of 860 nM. SGC-CK2-1 inhibits Duodenum Hutu 80 cells with an IC 50 of 920 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CK2α 36 nM (IC 50 ) CK2α' 16 nM (IC 50 )

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