VT02956 is a LATS inhibitor ( IC 50 : 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids. IC50& Target:IC50: 0.76 nM for LATS1, 0.52 nM for LATS2 In Vitro:VT02956 (2 μM, 0-30 min) reduces YAP/TAZ phosphorylation in HEK293A cells and 4T1 cells. VT02956 (2 μM, 2 days) reduces ERα and its target genes TFF1 and GREB1 in breast tumor organoids BTO-02. VT02956 (2 μM, 4 days) inhibits the proliferation o Biological Activity:VT02956 is a LATS inhibitor ( IC 50 : 0.76u2009nM for LATS1, 0.52u2009nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids.
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VT02956
CAS number：unknown molecular formula：C22H23N5O
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C22H23N5O |
| molecular weight | 373.45 g/mol | Exact mass | - |
| PSA | - | logp | - |
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