Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities. In Vitro Gypenoside L (20-80 μg/mL; 24 h) increases the mRNA expression levels of SASP, such as IL-1α, IL-6, TIMP-1, CXCL-1 and CXCL-2 in HepG2 and ECA-109 cells. Gypenoside L (20-80 μg/mL; 24 h) causes cell cycle arrest at S phase. GPL (3.125-100 μg/mL) significantly inhibits LPS-induced NO accumulation in RAW264.7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Gypenoside L
CAS number：94987-09-4 molecular formula：C42H72O14
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Specs
| Chinese alias | 绞股蓝皂苷 | ||
| English alias | DTXSID901317815 | Gypenoside L | E88708 | HY-N8211 | MS-31473 | (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(2R,3R,5R,8R,9R,10R,12R,13R,14R,17S)-2,12-Dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-d | ||
| CAS number | 94987-09-4 | molecular formula | C42H72O14 |
| molecular weight | 801.01 g/mol | Exact mass | ≥99% |
| PSA | 239.000 Ų | logp | 3.000 |
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