Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC 50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo In Vitro Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC 50 of 6.51 µM. Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 6.51 µM (SARS-CoV-2)
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Cleistanthin B
CAS number：30021-77-3 molecular formula：C27H26O12
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Specs
| Chinese alias | 闭花木素乙 | ||
| English alias | Naphtho(2,3-c)furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-4-(beta-D-glucopyranosyloxy)-6,7-dimethoxy- | 9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3H-benzo[f][2]benzofuran-1-one | 9-(1,3-benzod | ||
| CAS number | 30021-77-3 | molecular formula | C27H26O12 |
| molecular weight | 542.49 g/mol | Exact mass | ≥99% |
| PSA | 163.000 Ų | logp | 1.800 |
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