Pivalopril is a new orally active angiotensin converting enzyme ( ACE ) inhibitor. In Vivo Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED 50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED 50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:ACE
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Pivalopril
CAS number：81045-50-3 molecular formula：C16H27NO4S
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| Chinese alias | 匹伐普利 | ||
| English alias | 2-[cyclopentyl-[(2S)-3-(2,2-dimethylpropanoylsulanyl)-2-methylpropanoyl]amino]acetic acid | CHEBI:188840 | STK347863 | (S)-N-cyclopentyl-N-(2-methyl-3-(pivaloylthio)propanoyl)glycine | PIVOPRIL | USV 3659(S) | Benzimidazole, 2-amino-1-methyl- | p-Phenylbe | ||
| CAS number | 81045-50-3 | molecular formula | C16H27NO4S |
| molecular weight | 329.45 g/mol | Exact mass | ≥99% |
| PSA | 100.000 Ų | logp | 2.900 |
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