ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC 50 of 0.63 µM and a K i of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer In Vitro ALDH1A3-IN-1 (Compound 14) (0-200 µM, 96 h) shows antiproliferative activity in prostate cancer cell lines. ALDH1A3-IN-1 (0-200 µM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: PC3, LNCaP, and DU145 cells Concentration: 12.5-200 µM Incubation Time: 96 h Result: Showed antiproliferative activity with IC 50 values of 47 ± 6, 25 ± 1, and 61 ± 5 µM against PC3, LNCaP, and DU145 cells. Cell Viability AssayCell Line: Primary cells cultured at early passage from human prostate tissue biopsies Concentration: 50 and 200 μM Incubation Time: 72 h Result: Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures. Form:Liquid IC50& Target:ALDH1A3 0.63 μM (IC 50 ) ALDH1A1 7.08 μM (IC 50 ) ALDH3A1 8.00 μM (IC 50 ) ALDH1A3 0.46 μM (Ki) ALDH1A3 26.92 μM (Km)
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ALDH1A3-IN-1
CAS number：1695970-90-1 molecular formula：C13H18BrNO
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1695970-90-1 | molecular formula | C13H18BrNO |
| molecular weight | 284.19 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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