Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst 2 /sst 5 receptor partial agonist with IC 50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research In Vitro Angiopeptin (0.1 nM- 10 μM; for 1 h) TFA acts as a partial agonist (pEC 50 =6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst 2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Angiopeptin (20 and 50μg/kg; i.h.) TFA significantly inhibits neointimal formation . Angiopeptin (20 μg/kg; per day) TFA significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50% . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.26 nM (sst2) and 6.92 nM (sst5)
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Angiopeptin TFA
CAS number：2478421-60-0 molecular formula：C58H73F6N11O14S2
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| Chinese alias | 血管肽素TFA | ||
| English alias | - | ||
| CAS number | 2478421-60-0 | molecular formula | C58H73F6N11O14S2 |
| molecular weight | 1326.39 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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