SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC 50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. In Vitro SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 8 nM (binding MC-4), 5 nM (function MC-4)
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SNT-207707
CAS number：1064662-40-3(DMSO) molecular formula：C32H44ClN5O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1064662-40-3(DMSO) | molecular formula | C32H44ClN5O |
| molecular weight | 550.18 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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