PI3K/mTOR Inhibitor-13 sodium

PI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositol 3-kinase ( PI3K ) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF). In Vitro PI3K/mTOR Inhibitor-13 sodium (Compound A) (0-2 µM; 48 h) inhibits the proliferation of HFL1 cells with dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: HFL1 cells. Concentration: 0, 0.03125, 0.0125, 0.025, 0.05, 0.0625, 0.1, 0.125, 0.2, 0.25, 0.4, 0.5, 1 and 2 µM. Incubation Time: 48 h. Result: Showed inhibitory for HFL1 cells. Western Blot AnalysisCell Line: HFL1 cells. Concentration: 200 nM. Incubation Time: 48 h. Result: Increased the expression of α-SMA/Tubulin. In Vivo Pharmacokinetic (PK) parameters of PI3K/mTOR Inhibitor-13 sodiumSpecies Administration manner Dose (mg/kg) T 1/2 (h) AUC last (ng•h/mL) Cl/F (L/h/kg) V ss (L/kg) F (%) Rat Intravenous injection 2 2.77 7069 0.29 0.85 94.75 Mice Intravenous injection 1 5.45 57059 0.02 0.13 79.3 Dog Intravenous injection 1 0.67 3672 0.27 0.23 108.5 Monkey Intravenous injection 1 9.70 5978 0.16 0.92 59.8 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

No numbering system information yet

No physical and chemical property information yet

No safety information yet

No production method and use information yet

No upstream information yet

No downstream information yet

No related product information yet