IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC 50 s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1 R132H , IDH1 R132C , and IDH1 WT , respectively Anticancer activity In Vitro IDH1 Inhibitor 1 (Compound 19) inhibits cellular HCT116-IDH1 R132H/+ with an IC 50 of 0.039 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo IDH1 Inhibitor 1 (Compound 19) inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model. IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1 R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.021 μM (IDH1 R132H ), 0.045 μM (IDH1 R132C ), and 2.52 μM (IDH1 WT )
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IDH1 Inhibitor 1
CAS number：2234285-81-3 molecular formula：C20H18F4N6O2
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| Chinese alias | IDH1 抑制剂 1 | ||
| English alias | - | ||
| CAS number | 2234285-81-3 | molecular formula | C20H18F4N6O2 |
| molecular weight | 450.39 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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