ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2 , MMP-9 , and MMP-14 , with K i s of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound In Vivo ND-336 accelerates diabetic wound healing by decreasing inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thus reversing the pathological condition . ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female diabetic db/db mice Dosage: 0.05, 0.025, and 0.01 mg Administration: Topical application; daily for 14 day Result: Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle. Form:Solid IC50& Target:MMP-2 85 nM (Ki) MMP-9 150 nM (Ki) MMP-14 120 nM (Ki)
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ND-336
CAS number：1807453-83-3 molecular formula：C16H18ClNO3S2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1807453-83-3 | molecular formula | C16H18ClNO3S2 |
| molecular weight | 371.90 g/mol | Exact mass | - |
| PSA | - | logp | - |
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