CAS number：732983-37-8 molecular formula：C20H18N6O3
BAY 61-3606 (Syk inhibitor IV) 是一种具有活性的，ATP 竞争性的可逆选择性Syk 抑制剂。它作用于乳腺癌细胞，通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。它降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化，也降低 K-rn 细胞裂解物中 Syk 磷酸化 BAY 61-3606 (Syk inhibitor IV) is an active, ATP-competitive reversible selective Syk inhibitor. It acts on breast cancer cells and promotes TRAIL-induced apoptosis by down-regulating Mcl-1. It reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells, as well as Syk phosphorylation in K-rn cell lysates
| Chinese alias | - | ||
| English alias | Kinome_3125 | BAY-61-360 | UNII-61G8S0H9KX | BAY 61-3606 free base | CCG-102604 | AT32059 | BAY-61-3606 free base | DTXSID101017352 | HMS3295M09 | NCGC00346945-06 | AC-29888 | J-507625 | NCGC00346945-01 | 2-hydroxy-isonicotinic acid methyl ester | Syk inh | ||
| CAS number | 732983-37-8 | molecular formula | C20H18N6O3 |
| molecular weight | 390.40 g/mol | Exact mass | - |
| PSA | 117.000 Ų | logp | 3.300 |
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