Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
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Recombinant Human Frizzled-1 Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 卷曲同源物1(FZD1)重组蛋白 | 卷曲同源物1(FZD1)重组蛋白 | ||
| English alias | DKFZp564G072 | FLJ95923 | frizzled family receptor 1 | frizzled homolog 1 | frizzled, Drosophila, homolog of, 1 | Frizzled1 | Frizzled-1 | fz-1 | FZD1 | fzE1 | hFz1 | seven transmembrane spanning receptor | Wnt receptor | DKFZp564G072 | FLJ95923 | frizzle | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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