compound introduction
Origin: Native. Isolated from human peripheral blood polymorphonuclear leukocytes. Apparent Molecular Weight: approx. 150 kDa (contains 2 subunits each of a heavy chain with 64 kDa and a light chain with 13 kDa) Function Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
