CAS number：2166387-65-9 molecular formula：C24H29ClN6O3
BI-3802 是一种高效的 BCL6 降解剂，能够抑制 BCL6 的Bric-à-brac (BTB) 结构域，IC50 值 ≤3 nM。BI-3802 可诱导 BCL6 蛋白聚集，并促进 E3 连接酶 SIAH1 介导的蛋白降解。BI-3802 具有抗肿瘤活性。 Information BI-3802 BI-3802 is a highly potent oncogenic transcription factor BCL6 degrader with strong de-repression of target genes anti-proliferative effects. BI-3802 inhibits the BTB domain of BCL6 with IC50 of ≤3 nM. BI-3802 exhibits antitumor activity. Targets BTB domain of BCL6 (Cell-free assay) 3 nM
| Chinese alias | - | ||
| English alias | Acetamide,2-[[6-[[5-chloro-2-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,2-dihydro-1-methyl-2-oxo-3-quinolinyl]oxy]-N-methyl-,rel- | ||
| CAS number | 2166387-65-9 | molecular formula | C24H29ClN6O3 |
| molecular weight | 484.98 g/mol | Exact mass | - |
| PSA | 99.700 Ų | logp | 4.000 |
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