CP-10 is a PROTAC connected by ligands for Cereblon and CDK , with highly selective, specific, and remarkable CDK6 degradation ( DC 50 =2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6 In Vitro CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC 50 : 50-80 fold). ? CP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC 50 ≈10 nM) and mantle cell lymphoma cells (in Mino, IC 50 ≈8 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CDK6 2.1 nM (DC 50 ) Cereblon
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CP-10
CAS number：2366268-80-4 molecular formula：C44H49N13O7
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2366268-80-4 | molecular formula | C44H49N13O7 |
| molecular weight | 871.94 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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