INY-03-041 trihydrochloride is a potent, highly selective and PROTAC-based pan- AKT degrader consisting of the ATP-competitive AKT inhibitor Ipatasertib ( HY-15186 ) conjugated to Lenalidomide (HY-A0003, Cereblon ligand). INY-03-041 trihydrochloride inhib Appearance:Solid IC50& Target:Akt1 2.0 nM (IC 50 ) Akt3 3.5 nM (IC 50 ) Akt2 6.8 nM (IC 50 ) Cereblon In Vitro:INY-03-041 (10-1000 nM; 0-24 hours) induces potent degradation of all three AKT isoforms in MDA-MB-468 cells. INY-03-041 exhibits potent in vitro inhibition of S6K1 (IC 50 =37.3 nM) and PKG1 (IC 50 = 33.2 nM). INY-03-041 displays enhanced anti-p Biological Activity:INY-03-041 trihydrochloride is a potent, highly selective and PROTAC-based pan- AKT degrader consisting of the ATP-competitive AKT inhibitor Ipatasertib ( HY-15186 ) conjugated to Lenalidomide (HY-A0003, Cereblon ligand). INY-03-041 trihydrochloride inhib
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INY-03-041 trihydrochloride
CAS number：unknown molecular formula：C44H59Cl4N7O5
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| Chinese alias | INY-03-041 三盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C44H59Cl4N7O5 |
| molecular weight | 907.8 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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